Correlation of sperm DNA damage with protamine deficiency in Iranian subfertile men
نویسندگان
چکیده
منابع مشابه
Impact of DNA Damage on the Frequency of Sperm Chromosomal Aneuploidy in Normal and Subfertile Men
Background: Various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. Moreover, sperm DNA damage is shown to be associated with male infertility. In this study, the rate of DNA damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. Methods: Semen samples were obtained from healthy normal and subfertile ...
متن کاملP-62: Damage to Sperm DNA and Protamine Deficiency Induced by Risperidone in NMRI Mice
Background: Antipsychotic medication use is a common cause of hyperprolactinemia that shown to have adverse effects on male fertility. Risperidone is a combined serotonin/dopamine receptor antagonist that can cause elevations in prolactine level. Its mechanism of cytotoxic effects on testicular germ cells is not fully understood. In the present study we sought to elucidate the impact of risperi...
متن کاملimpact of dna damage on the frequency of sperm chromosomal aneuploidy in normal and subfertile men
background: various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. moreover, sperm dna damage is shown to be associated with male infertility. in this study, the rate of dna damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. methods: semen samples were obtained from healthy normal and subfertile ...
متن کاملEffect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI.
The aim of this study was to evaluate the effect of sperm DNA damage and protamine deficiency on fertilization and embryo development post-intracytoplasmic sperm injection (ICSI), and also to assess the effect of protamine deficiency on DNA damage. Semen samples were collected from 28 patients participating in the ICSI programme. Following sperm preparation and ICSI, the remaining processed sem...
متن کاملImpact of DNA damage on the frequency of sperm chromosomal aneuploidy in normal and subfertile men.
BACKGROUND Various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. Moreover, sperm DNA damage is shown to be associated with male infertility. In this study, the rate of DNA damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. METHODS Semen samples were obtained from healthy normal and subfertile ...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2009
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)60123-x